‘Single shot’ malaria vaccine delivery system could transform global immunization

Oxford researchers have developed programmable microcapsules to deliver vaccines in stages, potentially eliminating the need for booster shots and increasing immunization coverage in hard-to-reach communities.

A team of scientists at the University of Oxford has developed an innovative vaccine delivery system that could allow a full course of immunization—both initial and booster doses—to be delivered in just one injection. In preclinical trials, the technology provided strong protection against malaria, matching the efficacy of traditional multi-dose vaccination regimens.

Luca Bau, Senior Researcher from the Institute of Biomedical Engineering, said, “Reducing the number of clinic visits needed for full vaccination could make a major difference in communities where health care access is limited. Our goal is to help remove the barriers that stand in the way of people benefiting from life-saving medical innovations.”

The findings offer hope for a simpler, more effective approach to immunization, particularly in regions where access to follow-up health care is limited.

Sign up for Blog Updates