MedTech News

Immune ‘fingerprints’ aid diagnosis of complex diseases

Your immune system harbors a lifetime’s worth of information about threats it’s encountered—a biological Rolodex of baddies. Often the perpetrators are viruses and bacteria you’ve conquered; others are undercover agents like vaccines given to trigger protective immune responses or even red herrings in the form of healthy tissue caught in immunological crossfire.

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Scientists discover a new mechanism for how glioblastoma reprograms tumor-infiltrating neutrophils

The lab of Filippo Veglia, Ph.D., at The Wistar Institute has discovered a previously unknown mechanism for how aggressive brain cancers reprogram immune system cells from fighting cancer to enabling further tumor growth. The team’s findings were published in the paper “Functional reprogramming of neutrophils within the brain tumor microenvironment by hypoxia-driven histone lactylation,” from Cancer Discovery.

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Nasal spray shows preclinical promise for treating traumatic brain injury

A study led by researchers at Mass General Brigham suggests a nasal spray developed to target neuroinflammation could one day be an effective treatment for traumatic brain injury (TBI). By studying the effects of the nasal anti-CD3 in a mouse model of TBI, researchers found the spray could reduce damage to the central nervous system and behavioral deficits, suggesting a potential therapeutic approach for TBI and other acute forms of brain injury.

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New 4D brain map reveals potential early warning signs of multiple sclerosis

Using an animal model of multiple sclerosis (MS), researchers at the National Institutes of Health (NIH) have created a four-dimensional brain map that reveals how lesions similar to those seen in human MS form. These findings, published in Science, provide a window into the early disease state and could help identify potential targets for MS treatments and brain tissue repair.

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