New ultrasound imaging to map drug delivery into the brain

A new device combining ultrasound and advanced imaging to provide crucial information for the safe delivery of drugs into the brain has been developed by University of Queensland researchers. The research is published in the Journal of Controlled Release.

Dr. Pranesh Padmanabhan from UQ’s School of Biomedical Sciences and Queensland Brain Institute said the device allows real-time observation of individual cells after ultrasound treatment, which is an emerging technology for the delivery of drugs past the blood-brain barrier.

The information learned about how treated cells respond and change could ultimately benefit the treatment of neurodegenerative brain disorders such as Alzheimer’s and Parkinson’s disease.

“The blood-brain barrier prevents most drug uptake into the brain,” Dr. Padmanabhan said.

“Insights from this device will help inform ultrasound treatment protocols and establish a balance where uptake of drugs into the brain is effective, yet still safe.”

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