Trial Evaluating Blood Test for 10 Cancers Reaches Major Milestone

SOUTHAMPTON, England, July 30, 2025 /PRNewswire/ -- MODERNISED (NIHR207538), a multi-site UK clinical study has passed a key milestone: over 450 participants have joined the trial evaluating ENLIGHTEN®, a first-of-its-kind blood test, registered with the MHRA, and designed to spot signals of up to 10 cancers at their earliest, most treatable stages

Recruitment will continue to 1,000 newly diagnosed NHS cancer patients, and 350 symptomatic and healthy volunteers, from five hospitals across the country. The trial is run by University of Southampton researchers in partnership with the Southampton Clinical Trials Unit (SCTU) and Proteotype Diagnostics Ltd – and sponsored by University Hospital Southampton. Funding comes from the Office for Life Sciences (Department of Health and Social Care; Department for Science, Innovation and Technology) and the National Institute For Health and Care Research (NIHR) i4i programme.

Roughly 385,000 people are diagnosed with cancer in the UK each year, yet only four national screening programmes exist, each focused on a single cancer. Many cancers cause few or non-specific symptoms until advanced.

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