Hibernator ‘superpowers’ may lie hidden in human DNA

Animals that hibernate are incredibly resilient. They can spend months without food or water, muscles refusing to atrophy, body temperature dropping to near freezing as their metabolism and brain activity slow to a crawl. When they emerge from hibernation, they recover from dangerous health changes similar to those seen in type 2 diabetes, Alzheimer's disease, and stroke.

New genetic research suggests that hibernating animals’ superpowers could lie hidden in our own DNA—and provides clues on how to unlock them, opening the door to someday developing treatments that could reverse neurodegeneration and diabetes.

Two studies describing the results are published in Science.

The genetics of metabolism and obesity

A gene cluster called the “fat mass and obesity (FTO) locus” plays an important role in hibernators’ abilities, the researchers found. Intriguingly, humans have these genes too.

“What’s striking about this region is that it is the strongest genetic risk factor for human obesity,” says Chris Gregg, Ph.D., professor of neurobiology, anatomy, and human genetics at University of Utah Health and senior author on the studies. But hibernators seem able to use genes in the FTO locus in new ways to their advantage.

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