Using their newly developed machine learning framework, SIGNET, which reveals cause-and-effect relationships rather than simple genetic correlations, they uncovered key biological pathways that may drive memory loss and brain degeneration.

The study, published in Alzheimer’s & Dementia, also identifies new genes that could serve as targets for future treatments.

Alzheimer’s disease, the leading cause of dementia, is projected to affect nearly 14 million Americans by 2060. Scientists have already found many genes linked to the disease, such as APOE and APP, but they still don’t fully understand how these genes disrupt healthy brain function.

“Different types of brain cells play d