Epilepsy isn’t always easy to diagnose. Seizures often don’t occur during routine brain-wave recordings (EEGs), leaving doctors without the direct observation they need to make a clear diagnosis. 

In a proof-of-concept study in mice, the team showed that their approach can identify subtle EEG differences linked to a genetic form of epilepsy, even when no visible seizures occurred. The findings, published in the Journal of Neural Engineering, set the stage for the next phase of the research, which will test the method on EEGs from children being evaluated for epilepsy at Nemours Children’s Health.