The new method, published in Science, demonstrates for the first time that it is possible to design proteins in the computer for redirecting immune cells to target cancer cells through pMHC molecules.

This dramatically shortens the process of finding effective molecules for cancer treatment from years to a few weeks.

“We are essentially creating a new set of eyes for the immune system. Current methods for individual cancer treatment are based on finding so-called T-cell receptors in the immune system of a patient or donor that can be used for treatment. This is a very time-consuming and challenging process. Our platform designs molecular keys to target cancer cells using the AI platform, and it does so at incredible speed, so that a new lead molecule can be ready within 4-6 weeks,” says Associate Professor at the Technical University of Denmark (DTU) and last author of the study Timothy P. Jenkins.