Artificial saliva with sugarcane protein shields teeth after cancer treatment

An artificial saliva in the form of a mouthwash, produced with the CANECPI-5 protein extracted from sugarcane and modified in a laboratory, can aid in treating teeth in patients with head and neck cancer. In these cases, radiotherapy very close to the mouth can destroy salivary glands and compromise saliva production, which is essential for controlling bacteria and disease.

According to research conducted at the Bauru School of Dentistry at the University of São Paulo (FOB-USP) in Brazil, CANECPI-5 forms a protective “shield” for the teeth, guarding the enamel against weakening acids found in juices, alcoholic beverages, and even stomach acids.

The results are published in the Journal of Dentistry.

The study was conducted during Natara Dias Gomes da Silva’s doctoral studies at FOB-USP. She collaborated with researchers from the Federal University of São Carlos (UFSCar), also in Brazil; the University of California in San Francisco, in the United States; and Yonsei University College of Dentistry, in South Korea.

The work is part of the Thematic Project “Modulation of acquired pellicle to control dental mineral loss: unveiling mechanisms to make therapies possible,” which is coordinated by Professor Marília Afonso Rabelo Buzalaf from FOB-USP.

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