MedTech News
.................... by Andrew Celentano
Scientists reverse aging in blood stem cells by targeting lysosomal dysfunction
Researchers at the Icahn School of Medicine at Mount Sinai have discovered how to reverse aging in blood-forming stem cells in mice by correcting defects in the stem cell’s lysosomes. The breakthrough, published in Cell Stem Cell, identifies lysosomal hyperactivation and dysfunction as key drivers of stem cell aging and shows that restoring lysosomal slow degradation can revitalize aged stem cells and enhance their regenerative capacity.
‘Zap-and-freeze’ technique successfully used to watch human brain cell communication
Researchers at Johns Hopkins Medicine say they have used a “zap-and-freeze” technology to watch hard-to-see brain cell communications in living brain tissue from mice and humans.
Automated system enables real-time malignancy grading of prostate tumors
The precise identification of tumor boundaries during radical prostatectomy remains a major clinical challenge. As positive surgical margins occur in 15–40% of prostate cancer cases, the risk of postoperative recurrence and functional impairment is significantly increased.
Sequencing method can analyze millions of T cells at a fraction of the cost
Studying T cells, the immune cells most responsible for responding to infections and cancers, just received a significant boost in the form of a new technique from St. Jude Children’s Research Hospital
Five key blood proteins may reveal hidden danger of early death
Scientists believe the proteins (PLAUR, SERPINA3, CRIM1, DDR1 and LTBP2), that play key roles in the development of diseases such as cancer and inflammation, may also contribute to the risk of dying.
AI learns from the tree of life to support rare disease diagnosis
Researchers have created an artificial intelligence model that can identify which mutations in human proteins are most likely to cause disease, even when those mutations have never been seen before in any person.
Focused ultrasound with chemotherapy shows survival benefit for brain cancer patients, clinical trial finds
Patients with the deadliest form of brain cancer, glioblastoma, who received MRI-guided focused ultrasound with standard-of-care chemotherapy had a nearly 40% increase in overall survival in a landmark trial of 34 patients led by University of Maryland School of Medicine (UMSOM) researchers.
FDA greenlights Transmural Systems’ TAVR guidewire
Transmural Systems’ Telltale guide wire aims to prevent coronary obstruction by modifying the ‘leaflet’ tissue in high-risk patients undergoing TAVR.