Botox-like nerve blocking reveals potential way to fully regenerate skin without scarring

Could wounded skin someday regrow perfectly without scars? A new study by Harvard stem cell biologists published in Cell reveals a way to fully regenerate skin by unblocking an embryonic healing mechanism that shuts off after birth. Demonstrated on mice, the study suggests a potential means to develop similar therapies in human patients.

“Essentially, we found a way to make wound healing outcome a lot better by learning how embryos do this so well,” said Ya-Chieh Hsu, Professor of Stem Cell and Regenerative Biology, Principal Faculty Member at the Harvard Stem Cell Institute, and senior author of the new study.

“I’m excited because we pushed the needle in a really important direction. When we have a wound, most skin cell types cannot regenerate and we get a scar. But now I think we’ve found a way to change that, so that many cell types can regenerate and we don’t get a scar.”

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