Clotting protein presents a potential target in pancreatic cancer

Researchers at the Indiana University Melvin and Bren Simon Comprehensive Cancer Center have found that depleting a clotting protein made by the liver could slow down pancreatic cancer.

“It’s well known that pancreatic cancer patients have some of the highest rates of blood clots or deep-vein thrombosis, or DVTs,” said Fishel, an associate professor of pediatrics and the Myles Brand Scholar in Cancer Research at the IU School of Medicine. “We wanted to understand whether the proteins involved in blood coagulation and clotting are driving the disease or are a byproduct of the disease.” Fishel is also a researcher at the Herman B Wells Center for Pediatric Research and co-leader of the Cancer Biology and Microenvironment research program at the cancer center.

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