Discovery of lung-based blood stem cells may transform transplant therapies

Red blood cells carry oxygen from the lungs to every other organ, and blood-forming stem cells must make about 200 billion new red blood cells each day to keep the oxygen flowing.

For many years, scientists assumed that blood production took place in the bone marrow. But now, researchers at UCSF are showing it’s also happening in the lungs.

They found hematopoietic stem cells (HSCs) in human lung tissue that make red blood cells, as well as megakaryocytes, which produce the platelets that form blood clots. The findings appear Feb. 27 in the Blood Journal

The work suggests the lungs could be a potent source for life-saving stem cell transplants.

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