Engineered micro scaffolds show promise for helping people recover from severe muscle loss

When a car accident or athletic injury destroys more than 20% of a muscle's mass, the body faces a problem it often can't heal fully on its own. Without intervention, scar tissue fills the injury site and can leave patients with permanent weakness and limited mobility.

Now, researchers at the University of Oregon’s Knight Campus, led by Alycia Galindo, a Ph.D. candidate in Marian Hettiaratchi’s lab, are developing a potential solution: microscopic scaffolds that guide muscle cells to regenerate organized, functional tissue.

Their findings, published in Cellular and Molecular Bioegineering, and part of the 2025 Young Innovator collection, combine microstructures with biochemical cues, offering a blueprint for future medical technologies that could help damaged muscle heal faster and more effectively.

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