Engineered Salmonella deliver cancer-killing viruses, shrinking liver and pancreatic tumors in mice

Researchers at the University of Massachusetts Amherst have designed non-toxic Salmonella bacteria to deliver viruses that are safe to humans but potent against liver and pancreatic cancer tumors—two cancers with an extremely poor prognosis.

The researchers found that animal models treated with this combination of bacteria and viruses saw almost all their tumors eliminated and lived significantly longer.

“There’s so much more research to be done before this treatment could be available to humans, but the potential of giving years to a liver or pancreatic cancer patient is exciting,” says Neil Forbes, corresponding author and professor in the Riccio College of Engineering at UMass Amherst.

“Our goal is to build therapies that don’t just shrink tumors, but give patients real, lasting time,” says Shradha Khanduja, first author on the paper and UMass chemical engineering Ph.D. candidate.

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