Experimental cancer treatment disrupts cell communication to suppress tumor growth in animal tests

A research team has developed an anticancer treatment platform that simultaneously targets cancer cells and the surrounding cells that support them while blocking communication between the two.

The paper is published in the Journal of the American Chemical Society. The researchers were led by Professor Yoosoo Yang of the Department of Integrative Biotechnology at Sungkyunkwan University (SKKU), in collaboration with a research team led by Dr. Man Kyu Shim of the Korea Institute of Science and Technology (KIST).

A support network around cancer cells

Tumors do not grow through the activity of cancer cells alone. Cancer-associated fibroblasts (CAFs) and various immune cells gather around cancer cells, forming a complex community known as the tumor microenvironment. These cells communicate by exchanging extracellular vesicles (EVs), tiny packages that carry biological signals between cells.

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