The findings could help explain differences in responses to chemotherapy and may also have implications for immunotherapies that depend on stem-like T cells.
Macrophages limit T cell entry
T cells play an important role in the body’s ability to recognize and attack cancer. Certain “stem-like” T cells are particularly important because they can renew themselves and develop into other T cells that can attack cancer cells. They can therefore help sustain an immune response against a tumor over time and have also been shown to play an important role in responses to immunotherapy.