Giant DNA discovered in people’s mouths could impact oral health, immunity and even cancer risk

Researchers, including those at the University of Tokyo, have made a surprising discovery hiding in people's mouths: Inocles, giant DNA elements that had previously escaped detection. These appear to play a central role in helping bacteria adapt to the constantly changing environment of the mouth.

The findings, published in the journal Nature Communications, provide fresh insight into how oral bacteria colonize and persist in humans, with potential implications for health, disease and microbiome research.

You might think that modern medical science knows everything there is to know about the human body. But even within the last decade, small, previously unknown organs have been discovered, and there’s one area of human biology that is currently going through a research renaissance, the microbiome.

This includes familiar areas such as the gut microbiome, but also the oral microbiome.

Inspired in part by recent discoveries of extraneous DNA in the microbiome of soil, Project Research Associate Yuya Kiguchi and his team turned their sights to a large set of saliva samples collected by the Yutaka Suzuki Lab of the Graduate School of Frontier Sciences at the University of Tokyo. They wondered if they might find something similar in human saliva.

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