Glowing bacterial sensors detect gut illness in mice before symptoms emerge

University of British Columbia researchers have engineered gut bacteria that dim their fluorescent glow in the presence of illness. Their findings could improve how we diagnose problems in the gut by using bacteria that already live there. The work appears in Cell.

“Our biosensors could improve the ability to predict how diseases in the gut progress, identifying early changes that could aid preventative interventions,” said co-first author Juan Camilo Burckhardt (he/him), a doctoral candidate in the department of microbiology and immunology (MBIM).

The current gold standard methods for peering into the gut involve invasive procedures that can only provide a single snapshot of gut health. The UBC-developed biosensor, currently tested in mice, establishes a new technology that can provide noninvasive, continuous monitoring through stool samples.

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