Gold-coated microneedles can detect subtleties in how liver and kidneys process drugs in real time

Scientists have taken a giant leap forward with the development of tiny microneedles designed to detect subtle but critical changes in how the liver and kidneys process therapeutic drugs.

“Wearable microneedle biosensors promise real-time molecular monitoring for precision medicine but are limited by low sensitivity and tissue abrasion,” writes Dr. Jialun Zhu, lead author of a new study published in Science Translational Medicine.

“Overcoming these challenges, we recast electrode functionality not merely as a sensing substrate but as a mechanism for resilient, high signal-to-noise ratio measurements in tissue,” added Zhu, a bioengineer in UCLA’s Samueli School of Engineering.

In plainer English, the multidisciplinary UCLA team was able to get their system to work flawlessly compared with similar devices by other research groups

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