‘Guided missile’ drug molecule seeks out and destroys cancer’s genetic lifeline

Researchers have created a new type of drug molecule that can precisely destroy TERRA, an RNA molecule that helps certain cancer cells survive. Using advanced "RIBOTAC" technology, their compound finds TERRA inside cells and breaks it down without harming healthy molecules. This discovery could pave the way for a new generation of RNA-based cancer treatments, targeting the disease at its genetic roots rather than just its symptoms.

Scientists at the Hebrew University of Jerusalem developed the drug molecule. The research, published in Advanced Science, was led by Dr. Raphael I. Benhamou, Elias Khaskia, and Dipak Dahatonde from Hebrew University’s Faculty of Medicine. Their work focuses on a molecule called TERRA, which helps protect the ends of our chromosomes—the parts of our DNA that keep our cells healthy and stable.

When TERRA doesn’t work properly, it can cause problems with how cells age and divide. In some cancers, especially certain brain and bone cancers, cancer cells use TERRA to keep themselves alive and multiplying.

“We’ve created a tool that acts like a guided missile for bad RNA,” said Dr. Benhamou. “It can find TERRA inside cancer cells and make it disappear—without harming healthy parts of the cell.”

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