Hidden immune cells in the lung could lead to better flu vaccines

Most current flu vaccines—especially those given by injection—do not reliably build strong immune memory in the airways, leaving a gap in protection against initial infection and transmission.

In the new study, researchers focused on how the immune system builds and maintains these protective memory T cells. They discovered that a subset of monocytes, a type of immune cell normally thought to be short-lived, can persist in the lungs for months after influenza infection.

These long-lasting cells behave differently than expected. Instead of disappearing, they appear to support the formation of immune memory by helping memory T cells survive and function in the lung.

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