How pancreatic tumors use the MYC protein to evade immune detection

An international research team has succeeded in deciphering a key mechanism that controls the growth of pancreatic cancers.

The results of the study have been published in Cell. The research was primarily carried out by Leonie Uhl, Amel Aziba and Sinah Löbbert, along with other collaborators from the University of Würzburg (JMU), Massachusetts Institute of Technology (U.S.) and Würzburg University Hospital. The study was led by Martin Eilers, Chair of Biochemistry and Molecular Biology at JMU, as part of the Cancer Grand Challenges KOODAC team.

In their study, the researchers focused on a specific protein that has long been known in cancer research: the oncoprotein MYC.

“In many types of tumors, this protein is one of the central drivers of cell division and thus of uncontrolled tumor growth,” explains Eilers.

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