Lab-grown heart tissue beats on its own as sensors track force in real time

Scientists at Université de Montréal and its affiliated Centre de recherche Azrieli du CHU Sainte-Justine have made a major advance in their research into cardiovascular disease: They've created functional, three-dimensional heart tissue that can beat autonomously in vitro.

Described as “hearts on a chip,” the engineered heart tissues are produced through 3D bioprinting with a bio-ink developed in Savoji’s laboratory using patient-harvested stem cells, enabling personalized human heart models to be created.

Led by UdeM pharmacology and physiology professor Houman Savoji at his laboratory at CHU Sainte-Justine, along with UdeM Ph.D. student Ali Mousavi, the research is detailed in a study published in the journal Small. An initial version of the technology was published two years ago, in a study in Applied Materials Today.

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