Lab-grown mini-stomachs could boost understanding of rare diseases

Researchers at UCL and Great Ormond Street Hospital (GOSH) have developed the first-ever lab-grown mini-stomach that contains the key components of the full-sized human organ.

In a paper published in Nature Biomedical Engineering, the researchers explain how they isolated stem cells from patient stomach samples and grew them under special laboratory conditions in a petri dish to create mini-stomachs, known as organoids, that mimic the behavior of a human stomach.

They grew separate organoids for each of the three main stomach regions and then combined—or “assembled”—them into a single version, known as an assembloid version. This is the first time this has been successfully achieved.

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