Lung-on-a-chip with working immune system protects itself like a living organ

Georgia Tech and Vanderbilt researchers have built the first lung-on-a-chip with a working immune system, a breakthrough with the potential to reshape how we study disease, move beyond animal testing, and administer lifesaving therapies.

On a clear polymer chip, soft and pliable like a gummy bear, a microscopic lung comes alive—expanding, circulating, and, for the first time, protecting itself like a living organ.

For Ankur Singh, director of Georgia Tech’s Center for Immunoengineering, watching immune cells rush through the chip took his breath away. Singh co-directed the study with longtime collaborator Krishnendu “Krish” Roy, former Regents Professor and director of the NSF Center for Cell Manufacturing Technologies at Tech and now the Bruce and Bridgitt Evans dean of engineering and University Distinguished Professor at Vanderbilt University.

Rachel Ringquist, Roy’s graduate student, and now a postdoctoral fellow with Singh, led the work as part of her doctoral dissertation.

Sign up for Blog Updates