Major study examines endoscopies that fail to detect esophageal cancer

An endoscopy—using a fiber‐optic tube to peer inside the body and collect biopsy samples—can be an invaluable way to detect cancer of the esophagus. But sometimes, an endoscopy can miss esophageal cancer, which doesn't get detected until weeks or months later.

A study led by University of Colorado Cancer Center member Sachin Wani, MD, sought to better understand the problem, drawing on data from more than 15,000 individuals with newly diagnosed Barrett’s esophagus, the only precancerous condition for esophageal adenocarcinoma.

Esophageal adenocarcinoma is the most common type of esophageal cancer in the United States and is also more commonly diagnosed among men. It’s a deadly cancer with poor five‐year survival rates, and most patients with this cancer present at an advanced stage.

Researchers found a big gap between hospitals in how good they were at detecting cancer and dysplasia—pre‐cancerous abnormal conditions—on an initial endoscopy in patients with Barrett’s esophagus.

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