Analysis of the cells in the tissue chip provides essential new information that advances our understanding of plasma cell development and function. This model also supports testing of new therapies for infection prevention, inhibition of allergy and reduction of autoimmunity. The study is published in Science Advances.
“This innovative bioengineering platform provides a window into a hidden aspect of the function of the human immune system,” said John H. Powers III, M.D., acting director of NIH’s National Institute of Allergy and Infectious Diseases (NIAID).
“By emulating key elements of the immune system in this lymphoid and bone marrow-on-a-chip system, this tool provides opportunities to gather new insights that existing models do not offer.”