New technique discovers previously unknown population of immune cells in the Alzheimer’s brain

Researchers have discovered a previously unknown population of immune cells in the brains of Alzheimer's patients that is found almost exclusively in the vicinity of a specific type of pathological protein deposit.

A newly developed microscopy technique allows, for the first time, the visualization of more than 30 protein markers simultaneously in the human brain and uses bioinformatics to analyze their spatial relationships. 

The development could, in the future, bring about lasting changes not only in Alzheimer’s research but also in the investigation of tumors and other diseases. The method, known as CODEX-CNS, can visualize different cell types simultaneously, investigate their functional properties and, furthermore, analyze the spatial relationships between cells. The research findings have just been published in Nature Neuroscience.

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