New technique involving metal carbonyl allows researchers to track chemotherapy drugs inside cells

Scientists have made significant progress in developing cancer therapies that help patients across cancer types. However, they face limitations in determining the results of drug effectiveness, as well as ensuring even distribution among all cancer cells because of the highly compact nature of tumors. Researchers are working to change that by giving chemotherapy drugs a kind of chemical "signal" that allows them to be tracked inside of cells.

This research focuses on a transformed version of a widely used chemotherapy drug, doxorubicin, which makes the previously undetectable drug detectable.

The team driving this research includes Craig Richard, a postdoctoral research fellow at the Cancer Center at Illinois (CCIL), and Principal Scientist at Eli Lilly and Company, Pei-Hsuan Hsieh.

They’re using a version of doxorubicin also known as DOX-IR, which is modified by attaching a metal carbonyl, a chemical compound formed when a metal atom is bonded to one or more molecules of carbon monoxide, which acts as a labeled tracking device by absorbing infrared light, making it easy to detect the drug as it moves through cancer cells with an infrared microscope.

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