New toothpaste stops periodontal pathogens

Researchers at the Halle branch of the Fraunhofer Institute for Cell Therapy and Immunology IZI have identified a substance that selectively blocks harmful pathogens such as Porphyromonas gingivalis without affecting other bacteria.

The oral microbiome is home to more than 700 different bacterial species, of which only a few can cause periodontitis. These adhere to dental plaque, particularly along the gum line, where they trigger inflammation (gingivitis). This can potentially lead to chronic periodontitis, which does more than just cause receding gums and loose teeth. If these bacteria enter the bloodstream, they can also contribute to the development of diabetes, rheumatic disease, arthritis, cardiovascular disease, chronic inflammatory bowel disease and even Alzheimer’s disease.

Pathogenic bacteria are killed by conventional oral care products such as alcohol-based mouthwashes and products containing the antiseptic chlorhexidine, but these also eliminate beneficial microorganisms. When the oral microbiome re-establishes itself after treatment, pathogenic bacteria such as Porphyromonas gingivalis gain an early advantage because they proliferate particularly well in inflamed gum tissue. Beneficial bacteria grow more slowly, and the oral microbiome quickly shifts back from its natural balance into dysbiosis, allowing the disease to recur.

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