No-needle test can tell if flu/COVID vaccines are effective

A team of researchers at the University of Pittsburgh has developed a skin patch that can detect antibodies associated with COVID and flu infections. It's orders of magnitude more sensitive than existing tests, uses just a half volt of electricity, and can return results in 10 minutes.

Alexander Star, professor of chemistry in the Kenneth P. Dietrich School of Arts and Sciences, has also developed sensors using a similar platform to detect, among other substances, marijuana and fentanyl.

An antibody test can indicate whether a vaccine has successfully taught someone’s immune system to fight a specific virus. If a test indicates someone has mounted a strong enough response without a vaccine, they may not need to get a booster.

The sensor uses a virus-specific antigen attached to a carbon nanotube, which is 100,000 times smaller than a human hair. The sensor can be attached painlessly on the skin using a microneedle array which samples the fluids between skin cells. When an antibody binds to its partner antigen, the electrical properties of the nanotubes change, indicating their presence.

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