The study, led by Dr. Tal Laviv in the Faculty of Medical and Health Sciences at Tel Aviv University, is published in the journal Nature Methods.
The research team explains that cells in the human body constantly adjust their size and rate of division to adapt to their environment throughout life. This process is crucial for normal development, as cells go through periods of precise growth regulation. When this process is disrupted, it can lead to severe diseases such as cancer and developmental disorders.
In the brain, regulating cellular growth is especially critical during early brain development, which occurs in the first years of life. Many genes are involved in this regulation, but one gene in particular—PTEN (Phosphatase and Tensin Homologue)—plays a central role. Mutations in PTEN are linked to a variety of conditions, including autism, epilepsy, and cancer.