Overlooked hormone may be deadly driver of postmenopausal breast cancer in women with obesity

A new analysis of research into the most common type of breast cancer has zeroed in on an overlooked hormone that may be responsible for the increased risk of breast cancer death in postmenopausal women with obesity.

The most common and deadly form of this disease in women after menopause is estrogen receptor positive (ER+) breast cancer. According to Joyce Slingerland, MD, Ph.D., who co-leads the Cancer Host Interaction Program at Georgetown University’s Lombardi Comprehensive Cancer Center, the outlook for ER-positive breast cancer is particularly stark for postmenopausal women with obesity: They are more likely to be diagnosed with this form of the disease and they are two to three times more likely to die from it.

“That’s particularly concerning because it’s estimated that obesity will affect nearly half of women in the United States by the end of the decade,” Slingerland explained.

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