The JAX team includes co-senior author Karolina Palucka, professor and director of the NCI-designated Jackson Laboratory Cancer Center, and Ryan P. Englander, the study’s first author and a graduate student at The Jackson Laboratory enrolled in the UConn Health MD-Ph.D. graduate program.
Published in Science, the study shows that lung tumors can disable a key gene called STAT2, not through mutations, but instead by altering how its RNA instructions are processed through a mechanism known as RNA splicing. Using long-read RNA sequencing, the team discovered thousands of previously unrecognized RNA variants in lung tumors.