Potential new treatment for uncontrolled hypertension results in a 15-point reduction in systolic number

April 24, 2025
10:44 pm

Researchers at the University of California San Diego School of Medicine have identified a potential new treatment, an investigational drug called lorundrostat, for individuals with uncontrolled or treatment-resistant hypertension, commonly known as high blood pressure.

The study, published in the New England Journal of Medicine, found that clinical trial participants taking the new drug experienced a 15-point reduction in systolic blood pressure, the top number in a blood pressure reading, compared to a 7-point reduction for patients who received placebo.

“This study was designed to look at the impact of a novel medication in lowering blood pressure for individuals whose hypertension is inadequately controlled by current standard medications,” said Michael Wilkinson, MD, principal investigator for the study at UC San Diego School of Medicine and cardiologist at UC San Diego Health.

The multicenter, Phase II, nationwide clinical trial involved 285 participants, including patients at UC San Diego Health, and was done in collaboration with the Cleveland Clinic Coordinating Center for Clinical Research.

Potential new treatment for uncontrolled hypertension results in a 15-point reduction in systolic number

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