Researchers identify cellular stress-protection system that may help tumors withstand chemotherapy

Many cancer treatments work by exploiting weaknesses in tumor cells, overwhelming their ability to survive, repair damage or continue growing. Yet some cancer cells manage to survive treatment. A new study from Texas A&M University sheds light on one reason why: Some cancer cells have a survival toolkit.

The research team, led by Dr. Wenshe Liu, Regents Professor and Harry E. Bovay Jr. Chair in chemistry in the College of Arts and Sciences, has identified key components of a little-understood cellular pathway that appears to help cells cope with oxidative stress, a form of molecular damage triggered by normal metabolism—and many cancer treatments. The study, published in Nature Communications, suggests that blocking this protective system could make certain therapies more effective against cancer.

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