Researchers at Sylvester Comprehensive Cancer Center—part of the University of Miami Miller School of Medicine—working with collaborators at the University of California, San Francisco, and the Helen Diller Family Comprehensive Cancer Center, have developed CIPHER-seq, which enables simultaneous measurement of RNA and proteins within the same immune cell for a more complete view of immune responses.

“RNA gives us clues about where a cell is headed,” said Justin Taylor, M.D., a Sylvester physician-scientist and co-senior author of the study. “Proteins show us where it actually arrives, and this clearer picture could help scientists design better immunotherapies and help clinicians predict which patients are most likely to benefit from them.”