Test strip with enhanced technology could make way for more accessible diagnosis

A research team led by La Trobe University has developed a single-use test strip that could ultimately change how diseases like cancer are diagnosed. The research used enzymes to boost an electrical signal to detect disease-indicative molecules, also known as microRNAs.

The biosensor works in a similar way to glucose test strips, but senior researcher Dr. Saimon Moraes Silva said it was much more sensitive, detecting microRNAs in blood plasma at ultra-low concentrations that are up to a trillion times lower than glucose.

“MicroRNAs provide early clues about health and diseases like cancer but they can be difficult to detect even using standard laboratory methods like PCR tests because they are often present in tiny amounts in blood, plasma, and saliva,” Dr. Silva said.

Lead researcher and Ph.D. candidate Vatsala Pithaih said the team’s key breakthrough came from a specialized enzyme that amplified the biosensor test strip’s response.

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