Researchers used high-resolution microscopy and artificial intelligence to count individual oocytes within mouse ovaries across their lifespan. This enabled them to develop a three-dimensional map of the changes in the ovary over time. In total, they analyzed over 85,000 oocytes from 100 mouse ovaries.
“We measured the number and position of every single oocyte in the ovary across the reproductive lifespan of the mouse,” Elvan Böke, group leader at the Centre for Genomic Regulation (CRG) in Barcelona and senior author of the study, told Discover.