Chemotherapy can help treat many types of cancer. Chemo drugs aim to disrupt or destroy cancer cells, which tend to grow and divide quickly. But the drugs aren’t always effective, partly because tumor tissue can be so dense that drugs can’t penetrate the inner layers of cells. Chemo drugs can also damage healthy cells and cause unpleasant side effects.

In a study published in the journal ACS Applied Nano Materials, a team of researchers led by former CU Boulder graduate engineering student Shane Curry used two tools to soften tumors. They paired high-frequency ultrasound waves with a type of sound-responsive particle to reduce the protein content of tumors.

Andrew Goodwin, senior author of the study and associate professor in the Department of Chemical and Biological Engineering at CU Boulder, said softening tumors this way could make chemotherapy more likely to work.