Uncertainty-aware AI and lensfree holography enable reliable automated HER2 assessment for breast cancer diagnostics

The integration of AI into digital pathology has the potential to transform cancer diagnostics by enabling scalable, quantitative analysis of tissue specimens. However, widespread deployment of AI-assisted pathology remains challenged by the need for costly imaging infrastructure and the lack of reliable mechanisms to assess prediction confidence.

Researchers at the University of California, Los Angeles (UCLA) have developed an uncertainty-aware computational pathology platform that combines lensfree holographic imaging with deep learning to perform automated HER2 assessment in breast cancer tissue samples. The paper is published in the journal BME Frontiers.

HER2 (human epidermal growth factor receptor 2) is an important biomarker used in breast cancer diagnosis and treatment planning. Accurate HER2 scoring is essential because it directly influences therapeutic decisions and patient management.

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