World’s First Synthetic Cell With a Complete Life Cycle Marks Biology Breakthrough

In a preprint published in bioRxiv, the team describes SpudCell. The system could grow, copy its DNA, divide, and take in fresh materials from smaller bubble-like structures nearby. When the team gave one version a genetic change that helped it feed more efficiently, those cells grew faster and became more common over five generations.

The work brings researchers closer to a long-standing goal in synthetic biology, showing that basic life-like behaviors can be built from chemistry alone.

“This is likely the most exciting project I’ve ever worked on,” said Adamala in a press release. “We’ve replicated in chemistry what only used to be possible in biology: the complete set of behaviors of a cell. It proves that the most fundamental functions of life, like growth and replication, do not need a mysterious magical spark.”

The human genome has about 3 billion base pairs. Biologists had previously estimated that a minimal genome for a living cell could have around 113,000 base pairs. SpudCell’s genome is smaller, at 90,000 base pairs.

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