World’s only deuterium-labeled guinea pig helps scientists study metabolism

The method relies on the fact that deuterium, once in the body, participates in biochemical reactions alongside ordinary hydrogen and becomes incorporated into the carbon-hydrogen bonds of organic compounds.

A Skoltech scientist has raised the world’s only isotope-labeled guinea pig. For 156 days, the animal, named Khryun, was given only heavy water to drink. Such water is non-radioactive and has long been used in biomedical research as a way to “label” molecules: the natural isotope deuterium accumulates in the chemical bonds of organic compounds and serves as a tracer for tracking their formation and breakdown. This approach can be useful for studying human metabolism, including the development of personalized medicine methods. The research results are published in the International Journal of Molecular Sciences.

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