The lab of Filippo Veglia, Ph.D., at The Wistar Institute has discovered a previously unknown mechanism for how aggressive brain cancers reprogram immune system cells from fighting cancer to enabling further tumor growth. The team’s findings were published in the paper “Functional reprogramming of neutrophils within the brain tumor microenvironment by hypoxia-driven histone lactylation,” from Cancer Discovery.

A study led by researchers at Mass General Brigham suggests a nasal spray developed to target neuroinflammation could one day be an effective treatment for traumatic brain injury (TBI). By studying the effects of the nasal anti-CD3 in a mouse model of TBI, researchers found the spray could reduce damage to the central nervous system and behavioral deficits, suggesting a potential therapeutic approach for TBI and other acute forms of brain injury.

Red blood cells carry oxygen from the lungs to every other organ, and blood-forming stem cells must make about 200 billion new red blood cells each day to keep the oxygen flowing.

New therapies for managing aging could emerge from research into a new gene, which scientists have identified as a key driver of degeneration.

A machine learning algorithm running on a smartwatch demonstrated the ability to detect sudden loss of pulse with high specificity (99.99%) and moderate sensitivity (67.23%), according to a study led by Google Research. Designed to identify cardiac arrest events, the system can automatically place an emergency call when it senses an event has occurred, even if the user is unresponsive.