Mayo Clinic researchers have identified interleukin-23 receptor (IL-23R) as a significant biomarker of cellular senescence and aging in both mice and humans. Experiments show that IL-23R levels in the bloodstream increase with age and can decrease, reflecting senescent cell clearing, with senolytic therapies.
A new method of scanning lungs is able to show the effects of treatment on lung function in real time and enable experts to see the functioning of transplanted lungs. This could enable medics to identify any decline in lung function sooner.
A gesture as simple as a smile can often convey what words cannot. This is part of why nonverbal communication is so central to human interaction. It is also why facial nerve disorders and injuries can be devastating.
Physician-researchers with City of Hope have developed a way to add features to T cells to help them overcome mechanisms of chimeric antigen receptor (CAR) T cell therapy resistance. Their new system is outlined in a paper published in Nature Biomedical Engineering.
Cardiovascular disease continues to lead as the primary cause of death across the globe, taking millions of lives every year. Damage caused by these diseases is particularly difficult to repair, since the heart has minimal ability to regenerate itself. But what if we could reprogram the body’s own cells to restore damaged tissue? This question has been tackled by scientists at Korea University, led by Dr. Myeong-Hwa Song.
Everyone knows the health risks of carrying too much fat around the waist and hips, but UVA Health scientists are developing a noninvasive way to assess the health risks of unseen fat around the heart.
Giving more blood to anemic patients after a heart attack may save lives, according to a Rutgers Health–led study. The study, published in NEJM Evidence, affirms research conducted in 2023 that suggested mortality rate or recurrent heart attacks were more frequent in anemic patients who received less blood.
A new gene editing tool that helps cellular machinery skip parts of genes responsible for diseases has been applied to reduce the formation of amyloid-beta plaque precursors in a mouse model of Alzheimer’s disease, researchers at the University of Illinois Urbana-Champaign report.
Researchers with the Advanced Science Research Center at the CUNY Graduate Center (CUNY ASRC) have unveiled a critical mechanism that links cellular stress in the brain to the progression of Alzheimer’s disease (AD).
A discovery has highlighted lithium—a drug long used to treat bipolar disorder and depression—as a potential therapy for autism spectrum disorder (ASD). This research, conducted by a team at the Center for Synaptic Brain Dysfunctions within the Institute for Basic Science (IBS) led by Director Kim Eunjoon, reveals that lithium can restore brain function and alleviate behavioral symptoms in animal models of ASD caused by mutations in the Dyrk1a gene.