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- DISEASE ADVANCES

‘Eye-on-a-chip’ reveals trigger for steroid-induced glaucoma

The eye, like most organs, has an intricate plumbing system. Pressure builds when drainage is impaired, and this condition—glaucoma—can cause irreversible vision loss. Certain popular anti-inflammatory eye medications that contain steroids can in some cases compound the problem, although scientists have been at a loss to understand why.

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AI reveals how protein modifications link mutations to disease

Researchers at Baylor College of Medicine have developed an artificial intelligence (AI) model that reveals how protein modifications link genetic mutations to disease. The method, called DeepMVP and published in Nature Methods, significantly outperforms previously published models and has implications for the development of novel therapeutics.

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Universal plug-and-play CAR-T cell therapy could transform cancer immunotherapy

Researchers at the University of Chicago have developed a “universal” chimeric antigen receptor (CAR) platform that offers enhanced safety, adaptability, and the potential to overcome long-standing barriers in cancer immunotherapy. Promising initial testing results, published in Science Advances, suggest that this new form of CAR-T cell therapy could dramatically change the treatment landscape for certain cancers.

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