Researchers at Columbia Engineering have built a cancer therapy that makes bacteria and viruses work as a team. In a study published in Nature Biomedical Engineering, the Synthetic Biological Systems Lab shows how their system hides a virus inside a tumor-seeking bacterium, smuggles it past the immune system, and unleashes it inside cancerous tumors.

Researchers have discovered eight new genes associated with schizophrenia, in the largest exome-sequencing study of the disorder ever conducted. The breakthrough, made by scientists at the Centre for Neuropsychiatric Genetics and Genomics (CNGG) at Cardiff University, provides new information and improves the understanding and future treatment development for schizophrenia.

The brain imaging study found that changes in brain dopamine are linked to symptoms of psychosis, no matter whether a person has been diagnosed with schizophrenia, bipolar disorder, or major depression.

Over the past 20 years, a class of cancer drugs called CD40 agonist antibodies have shown great promise—and induced great disappointment.

Now, researchers publishing in ACS Applied Polymer Materials have created a reusable hydrogel that releases artificial saliva over time, which could help provide sustained relief from dry mouth.

Doctors treating kidney disease have long depended on trial-and-error to find the best therapies for individual patients. Now, new artificial intelligence (AI) tools developed by researchers in the Perelman School of Medicine and the Wharton School at the University of Pennsylvania can analyze kidney disease at the cellular level to match the most effective treatments and speed up solutions.

Algorithms submitted for an AI Challenge hosted by the Radiological Society of North America (RSNA) have shown excellent performance for detecting breast cancers on mammography images, increasing screening sensitivity while maintaining low recall rates, according to a study published in Radiology.