A new discovery from the lab of YouYang Zhao, Ph.D., from Stanley Manne Children’s Research Institute at Ann & Robert H. Lurie Children’s Hospital of Chicago, opens promising new directions for treatment of life-threatening lung injury caused by sepsis.
In a major step forward for cancer care, researchers at ChristianaCare’s Gene Editing Institute have shown that disabling the NRF2 gene with CRISPR technology can reverse chemotherapy resistance in lung cancer. The approach restores drug sensitivity and slows tumor growth. The findings are published in the journal Molecular Therapy Oncology.
University of Kentucky researchers have developed a new experimental model that could point the way toward more effective Alzheimer’s disease treatments by targeting one of the brain’s most important genes for risk and resilience.
Scientists at The Hospital for Sick Children (SickKids) have revealed a previously overlooked layer of genetic variation that could help explain why people experience disease differently, and why some treatments work better for certain populations.
Weill Cornell Medicine investigators have identified an early step in a cellular process that leads to inflammation in fat cells and may result in type 2 diabetes in people with obesity.
New approach could be applied to other complex, genetically influenced diseases like cancer, Parkinson’s
Four University of Rhode Island researchers have developed and tested a cost-effective, easy-to-use tabletop device that can generate pressure waves, mimicking the impact of blasts that can cause neurodegeneration. Their study was recently published in the journal Cell Reports Methods. The results will help URI’s Claudia Fallini and Riccardo Sirtori better study the development and progression of neurodegenerative diseases in their lab.
Rice University bioengineers have demonstrated a nonsurgical way to quiet a seizure-relevant brain circuit in an animal model. The team used low-intensity focused ultrasound to briefly open the blood-brain barrier (BBB) in the hippocampus, delivered an engineered gene therapy only to that region and later flipped an on-demand “dimmer switch” with an oral drug.
“This is really unprecedented. A single treatment that simultaneously lowered LDL cholesterol and triglycerides,” said Luke J. Laffin, M.D., lead study author and a preventive cardiologist at the Cleveland Clinic
An Osaka Metropolitan University team has used stem cells extracted from adipose, the body’s fatty tissue, to treat spine fractures in rats similar to those caused by osteoporosis in humans. These cells offer the advantages of being easy to collect, even from elderly individuals, and causing little stress to the body, suggesting a noninvasive way of treating bone diseases.