A new international study led by researchers at Karolinska Institutet demonstrates that it is possible to detect subtle changes in the brain and identify early signs of hereditary frontotemporal dementia using advanced brain imaging techniques. The study is published in Molecular Psychiatry.
Two new research papers from the Living Brain Project at Mount Sinai present what is, by several metrics, the largest investigation ever performed of the biology of the living human brain. The papers present unequivocal evidence that brain tissue from living people has a distinct molecular character, an observation that until now was missed because brain tissue from living people is rarely studied.
Uncontrolled bleeding during surgery remains one of the deadliest medical emergencies. Injuries to internal organs such as the liver or spleen are especially dangerous because bleeding is difficult to control and often life-threatening.
A friend’s struggles with arthritis and the finger braces used to manage it inspired research by a Carnegie Mellon University student that could make it easier for patients to follow rehabilitation plans, speed up recovery times and help people manage chronic conditions.
Researchers at the University of California, Irvine have developed a 3D human colon model integrated with bioelectronics to aid in colorectal cancer research and drug discovery. The “3D in vivo mimicking human colon” enables precision, personalized medicine and offers a more ethical, accurate and cost-effective alternative to traditional animal testing.
Stem cells in most organisms typically take cues from adjacent cells. But new research from the Stowers Institute for Medical Research reveals planarian stem cells ignore their nearest neighbors and instead respond to signals farther away in the body. This discovery may help explain the flatworm’s extraordinary ability to regenerate—and could offer clues for developing new ways to replace or repair tissues in humans.
The influenza A virus (IAV) has been the cause of six major flu pandemics, responsible for 50 to 100 million deaths globally. In the U.S. alone, it is estimated that despite seasonally updated vaccines, IAV infections still lead to 140,000 to 710,000 hospitalizations and 12,000 to 52,000 deaths annually.
Faulty versions of the LMNA gene can cause a wide range of health problems, including heart muscle disease (dilated cardiomyopathy) and muscle weakness (muscular dystrophies). Many of these diseases are caused by single-point mutations, which are changes to one DNA “letter” (base).
A study by the University of Portsmouth in England has mapped the biological journey of anxiety in the brain when people are faced with a no-win situation.
Researchers at Cincinnati Children’s Hospital Medical Center in collaboration with Roche, have developed a next-generation human liver organoid microarray platform that could help predict which drugs may cause harmful immune reactions in some people.